I personally prefer Ticket to Ride: Europe when playing all adults as there is a touch more complexity (but not so much as to make it overwhelming). But, I've played the original game with adult groups many times, and it's a good, fun, light game.
I do recommend considering picking up the 1910 expansion if you're going to play it with adults frequently - I find the bigger cards work better when you've got adult-sized hands ;-)
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