I went through one course of Accutane when I was 18. I had some cystic acne which topical applications and antibiotics didn't seem to touch.
It worked like a charm. The downsides were the blood tests, not being able to drink and really dry skin and lips.
I still have fairly dry skin on my face, and use a moisturizer daily. The dry air here and hard water don't help, as I don't need a moisturizer out at the coast. Otherwise, no ill effects I can think of and it pretty much eliminated my acne.
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