I like your choice 2 or 3 the best,
3 will be the cheaper partying option and probably give you more variety in terms of culture and architecture, mind you I've only been to a handful of cities in each list.
I went to the UK once and it seems pretty blah to me compared to the other options you have on your list. I would think you'd have more fun on options 2 and 3 if you're 21, while everything you do in option 1 you can probably do when you're 40 or 50 years old and not miss to much.
lots of good advice here regarding prague and berlin too, listen to it.
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