[PsYcNeT]

XPadder works (there are free versions floating around, the guy only made it pay only after his millionth download), and you can create different profiles for different programs.

I actually downloaded it because my Hitman: Blood Money (original DVD copy) on PC wasn't controller compatible (which I still find bizarre) and it works great.

If you tweak it too, you can also turn your XBox controller into a wireless mouse to use with your HTPC using XPadder, because it has mouse emulation modes.