If this is satellite imagery be careful. They may be geotiffs with spatial refrencing data in the header of the file. If your compression exercises strip this data, geo scientists will kill you. If you drop bit depth or resolution they will also kill you.
Do the tiffs have associated world files? .tfw?
Any lossy compression could result in compression artifacts that are very noticeable in GIS applications or large prints.
I'm not convinced that companies are going to want you to compress any raster imagery.
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