Europe might look small, but it's jam packed with stuff. If it were me and it was my first time, I would pick one region and stick to that. You can't do it all in 2 weeks, so might as well have a great time exploring one section.....chances are you'll be back for more anyway.
Some possibilities: Central/Northern France (and BeNeLux if you wish as they are small), Southern France/Northern Italy, Central Europe (Prague, Vienna, Budapest), Spain (it's a big a place and has tons of variety), Italy (I'd pick one region, probably start with Rome/Florence/Tuscany). I would leave some of the slightly less obvious destinations (ie, Croatia, or Scandinavia) for a future trip.
London, and then taking the train to Paris is always a nice trip too, especially for a first timer looking to really get that stereotypical European experience. They are obvious, but popular for a reason. Just don't got to Paris in August if you expect to see French people.
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