I've played co-ed in both the GHL and CSSC.
I think CSSC floor hockey is brutal. I'm not crazy about the rules, especially high sticking. I've found the game venues for the GHL are much better too.
I prefer the freedom of using actual sticks in GHL versus the plastic intramural ones you must use in CSSC. I also really like the consistency of the refs in GHL play.
Now...this might be a girl thing, but I feel much more comfortable with a real stick that's light, versus lugging around a clunky plastic one. This, of course, may only apply to me because I'm a weakling