Stay anywhere in the vicinity of the 16th street mall in downtown. Lots of hotels there. The further north you stay (towards LoDo) the closer you are to Mile High Stadium (about a 15 minute walk). Good nightlife on 16th St Mall, LoDo, Larimer St, etc. Not sure what kind of nightlife you want, but everything from pubs (Tilted Kilt) to bottle service (Suite 200). Coors tour in Golden is always fun. Denver is a good town, you'll have fun. Pepsi Center isn't a far walk either for an Avs game (and tickets are cheap!).
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