As far as actually sketchy areas - there are only very small isolated pockets such as 14th and 15th Avenues between Centre and 4th Street and right beside the Drop In.
Other areas are simply under-developed like along 10th, 11th and 12th near 14th Street, East Village (but that's changing fast) and the West end along 8th Avenue. But, with time all these will fill-in as well.
But really you can't go wrong with most places surrounding the commercial core.
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Trust the snake.
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