It sounds like the drive is defective. I don't know if what you have on the drive HAS to be recovered, but if not, then you can always remove the drive from the enclosure and hook the drive itself up via the SATA connector and do a secure erase. Another option is to connect the drive to another USB>SATA controller and see if you can access it.
Basically it is either a bad interface (the USB to the drives native SATA) or the drive itself is failing. Maybe someone else has better advice.
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