^ Well that question will likely be answered in the sequel, but it's likely that the Creators despised what they made (mankind), as we are ruining our Earth and creating life ourselves (such as David, the android). Then you have Guy Pearce asking for immortality which was guaranteed to make the situation even worse.
Heck mankind also seems to be responsible for the creation of xenomorph's which is just another reason why the creators would want to end our existence. They likely feel we our not only causing destruction of Earth, but also possibly the entire Universe. I imagine they are not too pleased with that.
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