I don't reply to recruiters if the job is not specific or looks like a mass email.
I am not too concerned as I don't plan on needing the services of a recruiter any time soon, but they get paid on placement so I don't think they will blackball.
That said, if I was considering a potential move in the near future I would absolutely reply that you are not interested for the following reasons. That way you are on top of their mind if something comes up that meets your reasons.
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