Try turning off all of your mail/calendar contacts synching, and also notifications from any 3rd part apps. I did this and gave it a hard reset (hold down both buttons until the device powers down and the apple reappears) and everything has been good since. I added back in my mail/calendar synching, and left the 3rd party app notifications off and I've been fine for a few weeks and with good battery life on my iPhone 4.
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