Any other time, I'd say the Saints would beat the Colts without Manning by at least 20 points. They'll be jacked to be playing at home for the first time in weeks, and they usually play well in national TV games (especially at home).
The only concern I have is that I'm curious how they'll perform with Coach Payton up in the booth vs. on the sideline. You'd think he'd be able to have a better vantage point up there to dissect the Colts defense, but any deviation from the norm in the NFL can lead to game changing results.
With that said, I'm confident in a big win, with the Saints D scoring some big fantasy points. For gambling purposes, I'd take the over, but I'm certainly no expert...
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