Many artificial sweeteners are former drugs. Aspartame previously was only available by prescription for diabetics only under physicians care. Sorbitol was formerly a laxative used by prescription. We have turned prescription drugs into daily consumables in high quantities. The body is going to have repercussions.
I don't believe the sweeteners are safe for the sheer fact that within minutes of consuming any of them I become violently sick. I have a number of food related allergies and NOTHING comes close to the reaction I get from a very small amount of any artificial sugar.
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