I have a Mac so went with Logic Pro 9. Love it. Used Pro Tools in college but had problems with it on my Mac so went with Logic. No complaints. It is miles above Garage Band.
Also have a Roland Fantom G8, which is a blast.
Yamaha DTXplorer
M-Audio Profire 610
M-Audio Axion 25 MIDI controller
2 M-Audio Studiophile Cx-5 monitors
And an Audio-technica At4040