At a high enough resolution I think you can, images can really look fuzzy. Heck even before LCDs to get good quality at really high resolutions you needed coaxial cable and BNC connectors.
At what resolution you'll be able to see a noticeable degradation depends on the connectors, the cable quality, the video card noise filters and DAC, etc.
DVI is digital so either you get the perfect image, or you get snow.
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