I just got back a week and a bit ago from Europe, including a few days in Berlin.
The previous comments about the autobahn are spot on. It really is just a nice, efficient highway. The suggested speed is 130, some people do more, some people do less. The best thing abaout it (again, already mentioned) is that people know how to drive it. Keep right, pass on the left, and get over as soon as you're done. We drove from Prague to Berlin (via Dresden) and it was smooth, efficient, but definitely not some wild west sort of thing.
The city itself is great for museums and galleries. It is actually quite intimidating as there are so many possibilities. They even have an island called "Museum Island" that has about 7 of them on there. We only had time for the Neus Museum, which is great if you're a fan of Egyptian artifacts, but after the first 3 floors I found myself getting a bit sick of them.
As with any German city, you can get around easily on the U-Bahn and the S-Bahn. Our hotel (as well as one in Frankfurt on a previous trip) can probably sell you a day pass which is good for 24 hours after first use. Just validate it at the station before your first trip and you're good. You can usually find a way to get to most of the main attractions by taking one or two trains at the most. Berlin is very spread out, but even if you have a car, you'll probably want to use the trains so you don't have to worry about parking.
And although I usually prefer not to take those "hop on, hop off" buses when I'm on holiday, my wife convinced me to do it on our first day there and it was quite beneficial. It was €20 I believe and the whole circuit took 2 hours and it really helped us get our bearings and discover some things that we may not have wanted to see otherwise, like the Potsdamer Platz area if you're in to shopping, for example.
What else? Umm... if you're going to see "We Will Rock You" and the ticket lady assures you that it is presented in equal amounts of German and English (I have seen theatre that has been subtitled even, so I believed her) - don't do it. All of the dialogue and half of the songs are in German. As much as I love Queen, I think that I still would have been disappointed if I could understand more of the dialogue. The music was good, but the story seemed a bit lame. Haha. I'm certainly not ignorant and expect everything to be presented in English for just for me, but I purchased the tickets based on some mis-information. Best to contact the theatres directly if you have questions as the ticket offices are probably commission-based.
If you like Indian food, we found a place called Amar to be great value and really good food. It was within walking distance from Schlesisches Tor U-Bahn station and was probably both our cheapest and best meal there. The best part about Berlin is that the neighbourhoods are very lively and vibrant. Lots of people around, lots of good restaurants, things are open late, etc.
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