As far as user friendliness, ease of adding data, etc., that's up to your designer. No web technology that outputs HTML is more or less user friendly than another. Just find a good designer.
I'm guessing that your virtual airline sites will more or less perform the same functions as a real airline site? Plus there will be an administrative section for scheduling virtual flights, etc. How many sites are you looking to build? Will they all be totally different branding or will switching logos suffice?
If I'm right in my assumptions this is going to be a pretty big job. I hope you're monetizing this somehow, because if you want this professionally done you'll need to be ready to part with a decent chunk of change.
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