I think that the San Diego game may be the toughest for the Colts considering that it is almost a must win for the Chargers now.
Seattle should have home field wrapped up by the time they play the Colts and would theoretically be resting guys as well. Unless Seattle feels that they need the game as a statement to the Colts and rest of the league I would think that both teams would be at an equal disadvantage when it came to resting players.
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