We still know so little about how the brain works in terms of chemical reactions in the brain, electrical reactions in the brain.
It wasn't that long ago that they figured that a lot of mental illness was caused my minor imbalances in a system that has millions of reactions per minute.
when you take any kind of drugs that target reactions, or drink any type of liquor there are long term damaging effects.
Your brain adapts to its usage, so when you stop using your brain has to react and basically rewire itself.
So to me there's a real possibility of some pretty screwed up reactions to withdrawl, and anxiety.
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My name is Ozymandias, King of Kings;
Look on my Works, ye Mighty, and despair!
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