For shopping, check out the Core (giant mall right downtown). If you're going to get ripped off, might as well do it under the world's largest sky light
If you've been there before, it's totally different now. Its most of the way through a huge renovation and it's actually pretty cool.
For going for some drinks, Hudsons is my favorite spot for a full on night out, Local 510 and 522 are not too bad for some beers either (one is downtown, one is on 17th, fairly similar). Bottlescrew bills is a not-so pretty place downtown with a HUGE beer selection.