I think you're generally fine if you're not involved with gangs, drugs, or any other violence-breeding activities of the like. Most homicides appear to be the work of past relationships gone sour, bad drug deals, and general animosity between two people.
It's important to know street-smarts here (as in any urban environment), but I'd say Calgary is still one of the best cities to live in. Our urban crawl is miniscule compared to that of larger cities.
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