Depending on how much you value your digital media I think it's important to back it up as well, not just your non-media files. In my case, its paramount - I've gone completely digital and have no DVD or CD media left in my house. Same for photos, they are all on my server and displayed on the HD TV. Mozy is only 5 bucks a month for unlimited online backups, I assume Carbonite and others are comparable.
The drobo and other consumer NAS/DAS (direct attached storage) devices are nice, but they don't have redundant power supplies, they have short warranties, and there is little to no guarantee that the internals are going to remain consistent across revisions, allowing you to move your disks to a new enclosure if it goes boom. They also don't protect against file system corruption, and worse, in the case of the Drobo, your partitions actually live on a lower level form of file system that is specific to the Drobo. If that low-level file system corrupts, I have no idea what you'd be able to do to recover from it.
So while I do agree that having some redundancy at the disk level is important, because its a guaranteed failure point (the reality is that disks begin to fail the second you turn them on - it just takes a long time on average until they are unusable) devices like the Drobo don't cover a lot of the other spectrum of failures that can potentially occur. They also don't like to talk about them on their website, which is a shame - they should take some responsibility in explaining where the Drobo fits into the spectrum of data availability and recoverability.
What I'm trying to say is that when you are planning large scale home storage systems, don't assume that buying a fancy consumer grade NAS or DAS is all you need to do (unless that data you are putting on it isn't worth anything). Put some thought into how you would handle a failure of that part of the overall system, and how much impact it would have on you, and put countermeasures in place from the start
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-Scott
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