They should just go the non-traditional route, IMO.
Make the movie a horror-porno. Cast Bruce Campbell as Spidey, Kathy Bates as Mary Jane and make the film's story where Peter is constantly trying to get laid from mutiple high school chicks, and then one day has to fend off the man-beast known as Mary Jane who falls in love with him (who also moonlights at night as the Kingpin). The movie's climax (no pun intended) is a classic showdown between Peter and Mary Jane in the cafeteria (Bates' lair) that leads into an uber-horror movie sequel where Bates tries to destroy Peter with sex in her birthday suit.
Get one of the Golden Girls to play Aunt May and cast her as a New York alley hooker, one that Peter has to constantly save from trouble, including drugs and booze. Kind of a side plot, if you will.
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