I'd avoid the tourist restaurants around Fisherman's Wharf. San Francisco is one of the best cities in the world for dining. I'll e-mail my friend that lives there and see what he recommends. He took me to a place owned by Robin Williams and Robert De Nero last time, but I forget the name of it.
People line-up for House of Nanking:
http://www.sanfrancisco.com/restaurants/chinatown.html
Chinese. Whether arriving early or late, everyone visiting House of Nanking will find themselves joining the crowd for a notoriously worthwhile wait on the sidewalk. This San Francisco Chinese restaurant takes a few creative liberties with the cuisine, preparing some dishes in an authentic way, but dressing up others with interesting (and very Americanized) accents. As this place is frequently packed, first-timers should remember to expect a loud and chaotic atmosphere, service that isn’t particularly friendly, and to be shoed the moment the last bite leaves the plate (lingering isn’t appreciated).
http://www.sanfrancisco.com/restaurants/