I would place family above all, both where I came from (parents and brother) and family I will start in the future (wife and kids). If I was forced to chose, I would give up my career for both. But maybe it's because I'm Asian, so in Asian cultures, they do place a lot of emphasis on close family bonds.
In fact, I expect my parents to help me take care of my kids in the future when me and the wife are working. That's just the way it goes for Asians. That way, I don't have to worry that my kids are being cared for by some unkown day care or babysitter. And grandma and grandpa are happy they get to spoil their grandkids. Win win both ways.
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