I'll be sticking to Heroes this Fall. Volume 3 got really weird and really dumb, but I felt Volume 4 made up for most of it and got it back to a lot of what made it successful in its first season (minus that STUPID GODAWFUL 50's FLASHBACK EPISODE GAH!!). Having seen the trailer for Volume 5, I have to say that there seems to be quite a coherent story and arc set in place, so I'll keep with it.
New shows I'll be trying out will be Glee and Flashforward, but only in passing. I learned my lesson the last few television seasons not to get invested in new shows until they've "established" themselves (i.e. not gotten cancelled after 1 or 2 seasons).
Also, props to kermit for mentioning Life. Man, I miss that show