There has been some concern about the leeching of chemicals out of plastics, especially when subjected to high heats. Tupperware has been pretty adamant that their microwave safe stuff is okay and safe, but I do know of quite a few people who have gone towards glass containers instead. I still have my tupperware and ziploc/gladware and use it, even in the microwave, though I have moved toward stainless water bottles.
My mom has tupperware from the 1980's that is still being used - so yeah, the lifespan on those is pretty darn good.
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