I'm currently unemployed, so I wouldn't quit that job.
Assuming that I won at least 20x the income that I had a month ago (before I lost my job), then I wouldn't look for additional work and I suspect that my wife would quit her job.
A majority of the money would be invested for income. The mortgage would be paid off and I'd pick up a nice watch or two.
I wouldn't be surprised if I started up a business eventually. I wouldn't likely start a capital intensive business unless I had won enough that I could risk it.