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CaptainCrunch · 05-05-2009, 03:59 PM

Just as an add on, after Thalidomide was pulled off of the market it was retested on several strains of pregnant animals and shown to cause birth defects in class a mice, Hamsters, Marmoset, Baboons and rats.

D. A. Blake, G. B. Gordon, & S.P. Spielberg, 'The role of metabolic activation in thalidomide teratogenesis', Teratology 25: 2 (1982), pp. 28A-29A.
J. A. DiPaolo, 'Congenital Malformation in Strain A Mice: Its Experimental Production by Thalidomide', Journal of the American Medical Association, 183 (1963), pp.139-141.
F. Homburger, S. Chaube, M. Eppenberger, P. D. Bogdonoff & and C.W. Nixon, 'Susceptibility of Certain Inbred Strains of Hamsters to Teratogenic Effects of Thalidomide', Toxicology and Applied Pharmacology, 7:5 (1965), pp. 686-69.
W. J. Hamilton & D. E. Poswillo, 'Limb Reduction Anomalies Induced in the Marmoset by Thalidomide', Journal of Anatomy 11 (1972), pp. 505-50.
A. G. Hendrick, L. R. Axelrod & L. D. Clayborn, 'Thalidomide Syndrome in Baboons', Nature, 210 (1966), pp. 958-95.
C. T. G. King CTG & F. J. Kendrick, 'Teratogenic Effects of Thalidomide in the Sprague Dawley Rat', The Lancet vol. ii (1962), p. 1116.
S. V. Rajkumar, 'Thalidomide: Tragic Past and Promising Future' Mayo Clinic Procedures 79:7 (2004).

Animal testing failed in this case because of failed methods.

05-05-2009, 03:59 PM	#306
CaptainCrunch Norm! Join Date: Jun 2002 Exp:	Just as an add on, after Thalidomide was pulled off of the market it was retested on several strains of pregnant animals and shown to cause birth defects in class a mice, Hamsters, Marmoset, Baboons and rats. D. A. Blake, G. B. Gordon, & S.P. Spielberg, 'The role of metabolic activation in thalidomide teratogenesis', Teratology 25: 2 (1982), pp. 28A-29A. J. A. DiPaolo, 'Congenital Malformation in Strain A Mice: Its Experimental Production by Thalidomide', Journal of the American Medical Association, 183 (1963), pp.139-141. F. Homburger, S. Chaube, M. Eppenberger, P. D. Bogdonoff & and C.W. Nixon, 'Susceptibility of Certain Inbred Strains of Hamsters to Teratogenic Effects of Thalidomide', Toxicology and Applied Pharmacology, 7:5 (1965), pp. 686-69. W. J. Hamilton & D. E. Poswillo, 'Limb Reduction Anomalies Induced in the Marmoset by Thalidomide', Journal of Anatomy 11 (1972), pp. 505-50. A. G. Hendrick, L. R. Axelrod & L. D. Clayborn, 'Thalidomide Syndrome in Baboons', Nature, 210 (1966), pp. 958-95. C. T. G. King CTG & F. J. Kendrick, 'Teratogenic Effects of Thalidomide in the Sprague Dawley Rat', The Lancet vol. ii (1962), p. 1116. S. V. Rajkumar, 'Thalidomide: Tragic Past and Promising Future' Mayo Clinic Procedures 79:7 (2004). Animal testing failed in this case because of failed methods. __________________ My name is Ozymandias, King of Kings; Look on my Works, ye Mighty, and despair!