I could see how it could definitely be a jump the shark moment, but we won't know for a while yet.
*Spoiler in white below*
The thing with relationships is once they become too central, it messes everything up. Often the writers try to counter by having the relationship on the rocks, but that just makes it even MORE central.
Hopefully they can keep the writing fresh by still having interesting patients and developing the other characters more.
Plus there's still a lot more they could do with House. What if, after leaving Cuddy's he pops some vicodin? Haha. Their going to have to show him adjusting to working with the pain somehow.
The trick will be keeping the qualities we love about him (or love to hate about him) while still showing he's growing. If he just does a 180 back to his old self people will probably dislike that too.
I don't think people mind seeing characters grow or change, as long as it's organic and natural, and they still see what brought them to the character in the first place.
This could ruin it in many ways, however, if the writing is smart they could keep it going without resorting to old tricks, repeating storyline, or cheese.
We shall see.
EDIT: Besides the obvious implications of the ending (two big changes) I thought it was a pretty good episode. Nice to see the doc messed up and vulnerable. Plus the case was interesting too. Skin coming off, ewwwww.
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