Turn indexing and superfetch back on!!
If you have 2GB of ram, double it.
If you have an accelerator card with on board ram, Aero will run just fine.
Open up your process list and look for the process that is eating disk time. Vista has an amazing resources utility which makes this a lot easier then in XP.
You might have an errant process going nuts that you can disable. My Vista machine did - turned out it was some stupid third party driver updater.
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