[Philly06Cup]

I put '######' in the same class of offensiveness as 'girl' and 'blind.'

"You throw like a girl."
"What are you, blind?!"

I don't find either of those expressions offensive. In the same vein, when my friend is slow-witted about something, I may call him a ######. Sometimes I may even call him mentally challenged.

The negative connotation doesn't come from the word '######' -- It comes from the fact that mentally challenged people are inferior to non-mentally challenged people. The same way that, generally speaking, girls are inferior to boys in terms of throwing and blind people are inferior to Seeing people.