My suggestion would be to take Deerfoot and Memorial (by far the fastest route to downtown), but then rather than taking the bridge into downtown, turn north on Edmonton Trail, and there's a Macs store after about two blocks. And then you can just take Edmonton Trail south across the river into downtown. Alternatively, there's also a Macs toward the west end of downtown, which may be convenient depending on your hotel location. (Not the nicest neighbourhood really late at night, but not exactly dangerous, either).
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