[Kybosh]

Looks like a lot of stuff packed into a relatively short time frame. It should be alright as long as you don't mind spending significant amounts of time on planes/trains/automobiles. The only thing I would suggest is to skip Frankfurt. If you want another German city, go to Munich instead.

In addition, I would suggest cutting out one or two areas from this trip so you can have more time to absorb in the other areas. For example, cut out Spain for this trip and leave it for another time. That can give you a few more days in Italy or France to see some things other than the big cities.