Travelocity isn't bad. Same with Priceline.
Recently, I've had some very good experiences with Hotwire.com (though it still may be limited to U.S. residents). I don't actually know a lot about it, other than the fact my family has used it numerous times to book deeply discounted rates for the types of hotel rooms we'd normally end up reserving at full price anyways. Worth a gander maybe.
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