I think you hit it on the head Hack&Lube, the competition isn't there so they don't have to try as hard..
Mind you we've never had a great price place in Calgary, I've always been able to find better deals out east and on the west coast.
For the most part I've got no problem with their prices.. Compared to other places in Calgary they're pretty competative (when comparing apples to apples). I've price matched NCIX before with them as well but that's hit and miss. With BCom in town now hopefully that'll put some pressure on their prices, but a lot of BCom's best prices are for things that Memory Express just doesn't carry (like the generic RAM for uber cheap).
http://www.dangeo.com is another local outfit that has some decent prices sometimes.