What video card do you have?
And where in WoW are these slowdowns occurring? Have you made it out of Azeroth into Outlands for instance?
Upping the resolution is going to start putting a high demand on your video card. There is a chance that your card just can put out WoW at full speed at that resolution.
The key things to adjust in WoW is the anti-aliasing, shadows, ansiotropic filtering and draw distance.
Also, WoW uses a dynamic caching system to make the world seamless as you move from zone to zone. If you hard drive/bus speed is relatively low, you will notice some slowdowns that arn't the fault of your video card.
You could also check if you're using an updated driver for your card. The ones that come on the CD usually are rushed out the door, barely qualified beta software.
Other major thing to check for is ensuring that you don't have many programs running in the background. Especially anti-virus packages like McAfee or Norton. Running a defrag on your hard drive might help as well since WoW tends to install everything into one monolithic file that becomes fragmented really easily.
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