Another branch from the San Francisco thread
I've heard it's fantastic in SF (probably next on my travel list) and saw that many other CP'ers hold the same view. I went to LA and San Diego last year, and thoroughly enjoyed both, although my favorite city in the US has to be Seattle. Good shopping (lots of outlet malls), Mariners/Seahawks games, no tax (if you're from Alberta), and not too far away.
What's on top of your list? New York? Chicago? Miami? Las Vegas?