I've had issues with the Memeo back-up software that is included with the drive and Vista 64 so I'm using Windows Backup. You can schedule regular backups and/or force a backup whenever you want. I like it because it's versioned and keeps a history (so say your computer crashed mid-back up, you always have the previous one to draw from). It's built on the same premise as Windows Restore is.
Memeo may be better, but I haven't used it...
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