Seeing as how the OP is in Richmond, I'd probably be making monthly trips down to Seattle because it's so close. Good shopping, Mariners/Seahawks games (depending on the time of year), and a cheap exchange rate.
Otherwise, LA and SF are close by for short and relatively cheap excursions from YVR; lots to see and do in both cities. Last year we flew to LA for a few days and then drove down to San Diego, which was really nice. Not really sure about the night life though...
Just do some research to see what you might like to do, and to maximize the time you have.
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