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Originally Posted by Momo
Well, unless there is someone out there who would like to volunteer to have their brains dissected and analyzed while they are on antidepressants...  There is no way of measuring increases in neurotransmitters. But if they can see that the drug is having an effect on their moods, why is that a bad thing?
Bottom line... just because they didn't work for you, doesn't mean they don't work. It is theorized that some depressions are biological (ie. caused by imbalances in neutrotransmitters) and some are not. It could also be that the depression eventually changes the chemistry in the brain and causes lower levels of neurotransmitters. There is no way to know for sure.
Many people will benefit from non-pharmacological therapy (eg. seeing a therapist or psychologist), but it is expensive. It should be recommended to everyone if they can afford it, and if it wasn't... there's the problem. Depending on the severity of the depression, getting cognitive therapy may not be enough. There is a need for antidepressants, but it is not needed for everyone.
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The Placebo effect during trials seems to have the same effect.
Theorys are all that the medical community has right now. It's the latest best guess as to what causes the so called chemical imbalance. When the medical community comes up with solid proof that they work, then i'll believe them.
It's not always expensive. There are places like the Calgary Counselling Centre that operate on a sliding fee scale where people pay what they can afford. I've used their services in the past and it didn't hurt me finacialy.