Settings? I've been playing guitar since I was a kid and never pay real attention to where everything is. Every room is different, sometimes you're far away from the amp, sometimes you're up close, depending on your mood everything changes. Just fiddle around until it sounds good to your ears and inspires you to play.
Plus, everyone has a different guitar, an el cheapo will be worlds apart from a Gretsch compared to an ESP, etc.
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