My favorite gaming weapon has/is trash talking my NHL nemesis to the point where they refuse to play anymore, then yelling forfeit over and over until they are out of earshot.
Unfortunately, that tactic has worked both ways in the past - to say we are NHL rivals would be an understatement. We're actually on a break this year, the Nabob Summit will have to wait until next year to resume.
the Anti-Material rifle in Mass Effect 2 is probably the most satisfying sniper rifle i've used in a game, it's more powerful than most of the actual heavy weapons you can use. same with the Quake 2 super shotgun, no other game since has had a shotgun that felt as powerful
i also have to give a nod to Gears of War for creating one of the most badass weapons ever, the assault rifle-chainsaw combo